SubQ Injections are as Effective as Intramuscular Injections, Study Says

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Doctor’s have been prescribing Testosterone to be administered Intramuscularly as a primary way of providing a Medical Transition. This means a longer needle, injection into the muscle fibers in large muscle groups such as your thigh or buttocks, and processing of the hormone into your bloodstream through said muscles.

Another option for injectable Hormone Replacement Therapy (HRT) acted sort of as an underdog to the regiment until recently.

With more research into the processes of the Endocrine System and its relationship with Adipose Tissue (Fat), scientists and medical researches have provided the community with another option.

SubQ or Subcutaneous injections (Read here for more information on the differences) have now been proven a safe, effective, and even preferred method of administering hormones.

A study done by a group of researches from the Maine Medical Center in Portland, Maine has published their finding on the matter in The Journal of Clinical Endocrinology & Metabolism (Volume 102, Issue 7). They wanted to know if the methods were equal in their delivery and effectiveness for a transition, mainly because of increased discomfort IM injections have been known to cause.

63 Trans Men, all over the age of 18 were involved.

With a starting dose of 50mg, and a weekly visit to monitor levels, check for injection irritation, and to administer the following dose, researchers aimed to achieve the average serum T level within a cisgender male.


“Serum T levels within the normal male range were achieved in all 63 patients with doses of 50 to 150 mg (median, 75/80 mg). Therapy was effective across a wide range of body mass index (19.0 to 49.9 kg/m2). Minor and transient local reactions were reported in 9 out of 63 patients. Among 53 premenopausal patients, 51 achieved amenorrhea and 35 achieved serum E2 concentrations <50 pg/mL. Twenty-two patients were originally receiving IM and switched to SC therapy. All 22 had a mild (n = 2) or marked (n = 20) preference for SC injections; none preferred IM injections.” – FULL STUDY

After the study concluded, patients were asked to rate their experience with SubQ injections with that of IM injections and there wasn’t a single person who preferred IM after experiencing SubQ.

Our observations indicate that SC T injections are an effective, safe, and well-accepted alternative to IM T injections.